The preparation of food, historically a domestic chore, became a highly profitable commercial enterprise. The recent surge in prevalence of the metabolic syndrome corresponds historically to the increase in consumption of lipogenic foods, which in the United States was the result of an unprecedented gastronomic revolution. The relationships of ectopic cholesterol and ceramide in the pathogenesis of the metabolic syndrome remain to be further established, but both cholesterol and ceramides are likely players with a negative impact. Similarly, the lipogenic arm has been proposed as a cause of the metabolic syndrome in persons with chronic caloric surplus. Ectopic cholesterol deposition in coronary arteries is a familiar cause of morbidity and mortality in the Western world, but is uncommon in populations that have not been exposed to high saturated fat diets. It is depicted to have a lipotoxic arm, well-established in rodents and humans, and hypothetical cholesterolotoxic and ceramidotoxic arms, each of which could result in potentially lethal disease caused by ectopic lipid deposition. The hypothetical gluttonicidal pathway depicted in Figure 1 would fit into this paradigm. If its only function is to increase risk of heart disease, could this signify that collective survival is protected at the expense of individual survival? Could elimination of gluttonous and slothful members of a society after their reproductive years assure the youngest members of the group a fair share of food during times of limited supply? The lethal consequences of co-morbidities of obesity can actually be “Darwinized” to explain the evolution of genes such as proprotein convertase subtilin/kexin type 9 (PCSK9), the only known function of which is to degrade the LDL receptor and thereby increase LDL-cholesterol in individuals who consume an atherogenic diet. Ceramidotoxicity, a potentially important metabolic aberration, is also not clearly identified in metabolic syndrome, but has been demonstrated to occur spontaneously in islets of ZDF rats with T2DM and metabolic syndrome. It should be pointed out that cholesterolotoxicity has not been demonstrated to occur spontaneously, but could exist (?) based on diabetes caused by transgenic overexpression of SREBP2 in β-cells. Middle-English slowthe, slow.A biological explanation for the morbid and mortal consequences of a gluttonous and slothful lifestyle, implicating nutrient-induced upregulation of lipogenesis, cholesterologenesis and ceramidogenesis to the point of lipotoxicity. This kind of laziness is directly opposed to the love of god and is one of the main reasons why some people, perhaps after years of virtuous living, give up on the pursuit of holiness or even become estranged from God. Sloth may also mean a repugnance to divine inpirations or the friendship of God due to the self-sacrifice and labor needed to co-operate with actual grace or to remain in the state of grace. It becomes sinful when the reluctance is allowed to influence the will and, as a result, what should have been done is either left undone or performed less well than a person is responsible for doing. As a sin, it is not to be confused with mere sadness over the inconvenience involved in fulfillin one's obligations, nor with the indeliberate feelings of repugnance when faced with unpleasant work. Implicit in sloth is the unwillingness to exert oneself in the performance of duty because of the sacrifice and the effort required.
The good work may be a corporal task, such as walking or a mental exercise, such as writing or a spiritual duty, such as prayer. Sluggishness of soul or boredom because of the exertion necessary for the performance of a good work. John Hardon's Modern Catholic Dictionary, © Eternal Life. Find accurate definitions of over 5,000 Catholic terms and phrases (including abbreviations).
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